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It is caused by one of the following: Lack of intrinsic factor. Intrinsic factor is a protein made in the stomach. It is needed to absorb vitamin B 12. This type of B 12 deficiency anemia is called pernicious anemia. Surgery that removes or bypasses the end of the small intestine. This part of the small intestine is where vitamin B 12 is absorbed. 2022. 2. 10. · A review of trials using vitamin B12 supplementation for depression found that fixing the deficiency can help manage depression. While taking vitamin B12 wasn’t a quick-fix for depressive symptoms, long-term supplementation can help manage depression. Vitamin B12 deficiency in children and adolescents can also affect mood. Normal vitamin B12 levels are about 200 - 900 pg. /mL, but it's not unusual to experience symptoms even if you are within the normal range. Some people start to feel better, more energetic, immediately; others don't notice improvements in memory or mood problems for a few weeks. Still others may not experience any relief for several months.